Filler brands at a glance: what actually differentiates them?
All the leading fillers in this guide are hyaluronic acid (HA) gels — a sugar your body already makes, reversible with the enzyme hyaluronidase. What separates brands is how the HA chains are crosslinked, their molecular weight, gel uniformity and additives such as lidocaine; these properties decide whether a gel suits a firm, projecting cheekbone or the paper-thin skin under the eye.
Two comparison anchors: "G-prime" (gel firmness — firmer gels for bony, volumising zones) and "documented longevity" (what trials showed, not what ads claim). A third factor is always present: injector skill, which no brand can compensate for.
All four are pre-filled, regulatory-filed HA products; newer market entrants may have far thinner clinical files.
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Juvéderm: the Vycross products and where each one belongs
Vycross blends light and heavy HA chains to deliver both softness and duration, which is why Vycross products tend to be long-lasting. Product names sometimes differ between Europe and the US (Volift is sold as Vollure in the US); the names differ, the composition does not.
Practical rule: moving toward Volbella the gel gets softer with better integration; toward Voluma and Volux it gets firmer with more lifting power. A firm gel is a poor lip choice, and a soft gel will not hold cheek volume.
Longevity depends on your metabolism, the zone and the volume injected; the figures above are published ranges, not guarantees.
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Restylane: NASHA/OBT technology and its workhorse products
NASHA’s hallmark is a gel that is firm yet not spongy, tending to cause less water-driven puffiness in delicate zones like the tear trough — one reason it has stayed on physicians’ under-eye shortlists for years. The OBT/Defyne generation is engineered for mobile areas (around the mouth) to look natural while talking and smiling.
Restylane Lyft is also one of the few fillers with a formal approval for the back of the hands — an example of how a brand’s clinical file can go well beyond headline longevity claims.
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Teosyal and the RHA series: gels engineered for a moving face
RHA’s core idea is preserving chain flexibility: gels that tolerate daily mechanical stress without breaking down. For patients worried about a "frozen" look, the resilient generation is a common pick.
Teosyal Redensity 2 is a recognised tear-trough product (a soft gel with lidocaine for thin skin), while Redensity [I] is the brand’s hydrating skin booster, covered on the mesotherapy brands page.
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Belotero: CPM technology and skin integration
CPM blends HA chains of differing density into one matrix; the result is a gel that works both deep and superficially without readily creating a visible blue tint under thin skin. That technical advantage still does not replace injector skill — under-eye injection demands experience with every brand.
For Iranian patients, Belotero Balance is one of the most frequently cited under-eye choices, and Revive (a glycerol-containing booster) appears in hydration plans; the product lineup organises just like other brands by firmness and zone.
Other filler brands: Korean, European and Chinese options you will meet
In the Iranian market import variety is high and a new brand appears almost yearly; some have genuine clinical files, others only attractive packaging. Instead of chasing "new names", check three things: is the product registered with a credible regulator? are there published studies? and does it arrive through an official channel with a traceable batch?
The brands below are known global examples; the list is not exhaustive and mention is not a recommendation.
For newer or lesser-known brands, clinical documentation may be limited; ask your physician to clarify registration status and studies.
Which brand/product for which zone? A practical map
This is the most-used table in the guide, with two serious caveats. First, "common choices" does not mean "the only right options" — an experienced physician can achieve good results with alternative products. Second, some zones (notably non-surgical rhinoplasty and the tear trough) are vascular high-risk areas; even the best brand cannot substitute for diagnosis, technique and complication management.
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Brand or injector: where does each one shape the result?
In practice, two scenarios produce most disappointing outcomes: the wrong gel for the zone (a firm gel in the lips, say) and the right product over-injected. Both trace back to the physician’s decisions, not the box. A good brand reduces risk; it never removes it.
Useful questions for your physician: why this product for this zone? what is its documented longevity? if I dislike the result, what is the reversal option (hyaluronidase)? and does the product come through an official channel with a traceable batch?
- Brand = gel properties & safety file; physician = diagnosis, technique and complication management.
- A zone-appropriate gel matters more than the priciest brand.
- Every HA brand has hyaluronidase as its reversal route; ask about it before injecting.
- Final price reflects brand, volume, the physician’s skill and the city — brand is only one input.
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Filler authenticity: what to check before the needle
Unlike oral medicines, filler is a product you can inspect before injection: packaging, labelling, sealed needle and batch number. A professional physician usually shows these; if showing the product is avoided with excuses, take it as a red flag.
The same rule applies to Korean and Chinese brands: some carry credible regulatory files, others do not — and you cannot tell from the name alone. Look at registration numbers, target markets and documentation instead.
- Match the box, batch number and expiry; laser printing on the vial must be legible and consistent.
- Packaging must open in front of you; filler should never be "pre-loaded" in a syringe or container.
- Ask how it was stored; heat and freezing both damage the gel structure.
- For HA fillers, hyaluronidase is the reversal route; confirm the clinic has access to it.
Summary: a quick brand-selection guide
The final decision is always personal: your anatomy, skin thickness, treatment history and expectations all shift the choice. This brand guide exists to help you ask your physician better questions — not to self-prescribe a brand.
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FAQ on this page
Short answers to the most common questions about this topic; for more depth see the full guide or theFAQ library (Persian).
References
We prioritise institutional sources (such as the FDA) and peer-reviewed papers. Citations whose link or identifier is not yet fully verified are flagged with "TODO: verify source". The complete bibliography (Persian) is on thereferences page.
- [1]Dermal Filler Devices (Hyaluronic Acid Based) — regulatory overview and approved indications — U.S. Food and Drug Administration (FDA)TODO: verify source — exact page slug should be double-checked.
- [2]Comparative physicochemical properties of hyaluronic acid dermal fillers — Peer-reviewed aesthetic surgery/dermatology literatureTODO: verify source — exact comparative study and DOI to be confirmed.
- [3]Juvéderm Vycross family — manufacturer product information — Allergan / AbbVieTODO: verify source — manufacturer document link to be confirmed.
- [4]Restylane NASHA/OBT family — manufacturer product information — Galderma / Q-MedTODO: verify source — manufacturer document link to be confirmed.
- [5]Teosyal RHA collection — manufacturer product information — TeoxaneTODO: verify source — manufacturer document link to be confirmed.
- [6]Belotero CPM family — manufacturer product information — Merz AestheticsTODO: verify source — manufacturer document link to be confirmed.
Related reading
Mesotherapy brands compared
Cocktails, boosters, polynucleotides and hair products by goal.
Filler hub page (Persian)
Filler types, longevity, side effects and aftercare.
Filler cost guide (Persian)
What drives filler pricing — and the brand’s share in it.
Injection safety & side effects (Persian)
Common, rare and emergency warning signs.
Medical disclaimer
All content on this website is for general education and information only and is not a substitute for medical examination, diagnosis or treatment advice. Every decision about aesthetic injections is personal and depends on your condition; always consult a licensed physician specialising in skin before any procedure.